Imatinib (Gleevec) for CML Treatment


Imatinib is shown for the treatment of patients with CML in impact emergency, quickened stage, or in incessant stage after disappointment with interferon treatment. 


The prescribed portion of imatinib is 400 mg every day for patients in constant stage CML and 600 mg day by day for patients with quickened stage or impact emergency. The portion might be expanded if there is ailment movement, lacking hematologic reaction following 3 months of treatment, or the passing of a formerly accomplished reaction. For patients with incessant stage CML, the portion might be expanded from 400 mg day by day to 600 mg every day whenever endured (ie, nonattendance of extreme unfriendly hematologic or nonhematologic responses). For patients with quickened stage or impact emergency the portion might be expanded from 600 mg to 800 mg (400 mg twice daily).1 The medication ought to be taken with a dinner and with a huge glass of water to diminish gastrointestinal bothering. The medication ought to be proceeded as long as it stays successful. 

The portion ought to be balanced or retained if extreme nonhematologic unfavorable responses (hepatotoxicity or liquid maintenance) or serious hematologic unfriendly responses (neutropenia or thrombocytopenia) happen. Complete blood checks ought to be performed week by week for the main month and fortnightly for the second month of treatment, and each 2-3 months from that point. 

Imatinib is provided as 100 mg cases. 

Potential Advantages 

Imatinib seems to have noteworthy points of interest over current treatments for CML, for example, interferon alpha. Imatinib price seems to have a superior and increasingly fast reaction, less unfriendly impacts, and can be given orally.2,4 It likewise seems, by all accounts, to be viable in patients who have bombed interferon treatment. 

Potential Disadvantages 

The most regular symptoms are sickness (55-68%), regurgitating (28-54%), liquid maintenance (52-58%), the runs (33-49%), and muscle cramps (25-46%). Extreme liquid maintenance (eg, pleural radiation, pericardial emission, aspiratory edema, ascites) has been accounted for in 1-2% of patients and increments with higher imatinib portion and age more seasoned than 65 years. Extreme shallow edema has been accounted for in 1-3% of patients. Cytopenias are progressively visit with patients with quickened CML or shoot emergency than with ceaseless stage CML. The frequencies of cytopenias go from 16-30% for grade 3 and 8-46% for grade 4. The recurrence of pallor was 4-40% and under 1-10%, individually. Serious rise of transaminases or bilirubin can likewise happen and the patients ought to be checked at benchmark and month to month or as clinically demonstrated. 

Because of the assisted FDA endorsement and constrained follow-up time, toxicities because of long haul use are not known.